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naturesQue ColTect P

Xenogeneic porcine barrier membrane

Assuming that the clinical requirements for a barrier membrane are satisfied, individual preferences for the handling properties play a major role in the choice of collagen membranes. The easy handling of naturesQue ColTect P enables diverse applications in therapeutic concepts that include the use of regenerative measures.


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Structure, design, and stability

naturesQue ColTect P is manufactured from purified collagen-rich tissue. Using a gentle method, the collagen is minimally crosslinked to give the membrane a predictable resorption profile with maximum tissue tolerability. A crosslinked structure prevents premature enzymatic cleavage of the collagen fibers and gives
naturesQue ColTect P a reproducible and reliable barrier function that is adapted to the time profile of bone healing.

This produces a highly versatile and strong membrane with comfortable handling properties.
naturesQue ColTect P is made up of a layer of intact collagen fibers. The membrane is not side specific.

Requirements profile for a collagen membrane

Collagen membranes alone do not have sufficient mechanical stability to shape and protect defect contours. For this reason naturesQue ColTect P is used together with bone substitute materials such as naturesQue SemOss B or naturesQue MaxOss P.

The use of bone substitute materials creates a volumizing framework in the defect space that is used by the osteoblasts as a substrate for bone deposition.

A barrier membrane protects the spaces in the bone defect and prevents the ingrowth of soft tissues. The job of the membrane is to establish and maintain a barrier that is permeable to nutrients between the bone and soft tissue. The membrane also stabilizes the augmentation material by covering the bone defect. The barrier function of naturesQue ColTect P lasts about 3 months, which is sufficiently long to ensure adequate bone healing.

Handling and feel

The naturesQue ColTect P membrane can be applied wet or dry. The membrane is cut to size so that the piece overlaps the margin of the defect by about 2 mm. When dry, naturesQue ColTect P is a sturdy, stable membrane. Wetting the membrane with saline or blood makes naturesQue ColTect P flexible, enabling it to be adapted to the defect contours.

It is not usually necessary to fix naturesQue ColTect P because the membrane can be easily wetted and adheres to the bone walls. Nevertheless, naturesQue ColTect P can be repositioned should this be necessary. If needed, naturesQue ColTect P can be sutured or fixed with pins.

naturesQue ColTect P put into context

Origin
  • Porcine peritoneum
Composition
  • Intact collagen fibers
  • Stabilized by reliable minimal crosslinking
Processing
  • Collagen-rich peritoneum
  • Cleaning and removal of non-collagenous proteins
  • Stabilization of the collagen fibers using minimal crosslinking
  • Washing, rinsing, and drying
  • Measurement, packaging, and sterilization
  • Quality Control
Application
  • Remove with sterile instruments
  • Processed wet or dry
  • Adapt to the size of the defect, overlapping by about 2 mm
  • Closed healing is recommended
  • No specific side for positioning
  • Can be repositioned
Consistency/Feel
  • Dry: Stable and rigid, sturdy
  • Wet: Can be draped, sturdy, adhesive, not sticky
  • Does not stretch
  • Tear resistant
Resorption
  • Resorption time between 12 and 16 weeks

Publikationen naturesQue ColTect P

Guarnieri R, Stefanelli L, De Angelis F, Mencio F, Pompa G, Di Carlo S. Extraction Socket Preservation Using Porcine-Derived Collagen Membrane Alone or Associated with Porcine-Derived Bone. Clinical Results of Randomized Controlled Study. Journal of Oral & Maxillofacial Research. 2017;8(3):e5,1-9**
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Guarnieri R, DeVilliers P, Grande M, Stefanelli LV, Di Carlo S, Pompa G. Histologic evaluation of bone healing of adjacent alveolar sockets grafted with bovine–and porcine-derived bone: a comparative case report in humans. Regenerative Biomaterials. 2017;125-128**

Guarnieri R, Testarelli L, Stefanelli L, De Angelis F, Mencio F, Pompa G, Di Carlo S. Bone Healing in Extraction Sockets Covered With Collagen Membrane Alone or Associated With Porcine-Derived Bone Graft: a Comparative Histological and Histomorphometric Analysis. Journal of Oral & Maxillofacial Research. 2017;8(4):1-9**
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Li ST, Yuen D, Martin D, Lee NS. New Porcine Collagen Membrane to Bio-Gide®A Comparative Study of a New Porcine Collagen Membrane to Bio-Gide®. Science, Technology, Innovation. 2015;1-5*
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*MatrixFlex is a trade name from Collagen Matrix Inc. and identical to naturesQue ColTect P
**Mem-Lok Pliable is a trade name from BioHorizons and identical to naturesQue ColTect P