The exceptional ability of bone tissue to regenerate is fascinating. This complex tissue heals almost without forming scars and recovers its original structure and functionality. The jumping distance that osteoblasts can bridge and the dimensions of the critical size defects that are used in study models impressively demonstrate not the limits but rather the potential of bone for regeneration.
The essential factors for bone regeneration are an adequate blood supply, mechanical support in the form of a guiding structure, and rest. Bone substitute materials are used for the regeneration of bone where the human body is not able to heal the bones itself. Along with the requirements 10 for an ideal bone substitute material, it is a generally accepted paradigm that bone substitute materials should mimic human cancellous bone as closely as possible [1].
The natural origin of xenogeneic bone substitute material gives it an optimal design. Porosity, pore distribution, and pore size correspond largely to those of human bone and are suitable to achieve bone formation, maturation, and remodeling. However, the purification of animal bone leads to a reduction in mechanical strength and biological potency, because cells and proteins have to be removed to eliminate the risk of transmitting disease and of rejection.
The xenohybrid bone substitute material naturesQue SemOss B is one of the new generation of regenerative nature-based regeneration materials. The combination of different material classes compensates for the limitations of the individual elements and amplifies their positive properties.
The established inorganic bone mineral naturesQue MaxOss P is obtained from porcine cancellous bone. The matrix is very porous and also provides ample space for new bone apposition and the remodeling processes during bone maturation.